Canonical and non-canonical roles of oligodendrocyte precursor cells in mental disorders

Journal article

Giulia Poggi, Giulia Treccani, Martina von der Bey, A. Tanti, M. Schmeisser, M. Müller
npj Mental Health Research, 2025

Semantic Scholar DOI PubMedCentral PubMed

Cite

APA Click to copy
Poggi, G., Treccani, G., von der Bey, M., Tanti, A., Schmeisser, M., & Müller, M. (2025). Canonical and non-canonical roles of oligodendrocyte precursor cells in mental disorders. Npj Mental Health Research.

Chicago/Turabian Click to copy
Poggi, Giulia, Giulia Treccani, Martina von der Bey, A. Tanti, M. Schmeisser, and M. Müller. “Canonical and Non-Canonical Roles of Oligodendrocyte Precursor Cells in Mental Disorders.” npj Mental Health Research (2025).

MLA Click to copy
Poggi, Giulia, et al. “Canonical and Non-Canonical Roles of Oligodendrocyte Precursor Cells in Mental Disorders.” Npj Mental Health Research, 2025.

BibTeX Click to copy

@article{giulia2025a,
  title = {Canonical and non-canonical roles of oligodendrocyte precursor cells in mental disorders},
  year = {2025},
  journal = {npj Mental Health Research},
  author = {Poggi, Giulia and Treccani, Giulia and von der Bey, Martina and Tanti, A. and Schmeisser, M. and Müller, M.}
}

Abstract

Psychiatric research has shifted from a neuroncentric view to understanding mental disorders as disturbances of heterogeneous brain networks. Oligodendrocyte precursor cells (OPCs)— actively involved in the modulation of neuronal functions – are altered in psychiatric patients, but the extent and related consequences are unclear. This review explores canonical and non-canonical OPC-related pathways in schizophrenia, bipolar disorder, post-traumatic stress disorder, and depression in humans, highlighting potential mechanisms shared across diagnostic entities.